| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
A model for the RecA protein of Mycoplasma synoviae
|
| Autores: |
Fonseca,Marbella Maria
Alarcon,Frank J.B.
Vasconcelos,Ana Tereza de
Agnez-Lima,Lucymara Fassarela
|
| Data: |
2007-01-01
|
| Ano: |
2007
|
| Palavras-chave: |
DNA repair
Recombination
RecA
Mycoplasma synoviae
|
| Resumo: |
In this work, we predict a structural model for the RecA protein from M. synoviae (MsRecA) by theoretical homology modeling and evaluate the occurrence of polymorphisms in this protein within several isolates of this species. The structural model suggested for MsRecA conserves the main domains present in MtRecA and EcRecA. The L1 and L2 regions showed six and three amino acid substitutions, respectively, which apparently do not affect the conformation and function of MsRecA. The C-terminal domain is shorter than that found in EcRecA and MtRecA, which may increase its capacity to bind dsDNA and displace SSB, compensating the absence of recombination initiation enzymes. The MS59 isolate RecA sequence showed one polymorphism which does not affect its functions since these belong to the same physical-chemical group.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200018
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572007000200018
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.30 n.1 suppl.0 2007
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
